منابع مشابه
BMP-9 balances endothelial cell fate.
The lymphatic system regulates tissue fluid homeostasis and acts as a conduit for leukocytes. Under high hydrostatic pressure, the blood system delivers oxygen, nutrients, and hormones to distant cells, while acellular fluid is forced out of blood capillaries into interstitial space. Most of this fluid drains back into lymphatic capillaries that are under low pressure and leaky due to their uni...
متن کاملVE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activ...
متن کاملBMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production
BACKGROUND Bone morphogenetic proteins (BMPs) and their receptors, such as bone morphogenetic protein receptor (BMPR) II, have been implicated in a wide variety of disorders including pulmonary arterial hypertension (PAH). Similarly, endothelin-1 (ET-1), a mitogen and vasoconstrictor, is upregulated in PAH and endothelin receptor antagonists are used in its treatment. We sought to determine whe...
متن کاملBMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo.
Members of the bone morphogenetic protein (BMP) family have been implicated in the development and maintenance of vascular systems. Whereas members of the BMP-2/4 and osteogenic protein-1 groups signal via activin receptor-like kinase (ALK)-2, ALK-3 and ALK-6, BMP-9 and BMP-10 have been reported to bind to ALK-1 in endothelial cells. However, the roles of BMP-9-ALK-1 signaling in the regulation...
متن کاملDetermination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation
We previously developed a novel method for gene transfer, which combined a non-viral gene expression vector with transcutaneous in vivo electroporation. We applied this method to transfer the bone morphogenetic protein (BMP) gene and induce ectopic bone formation in rat skeletal muscles. At present, it remains unclear which types of cells can differentiate into osteogenic cells after BMP gene t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1318346110